|
KMID : 0606920160240010067
|
|
Biomolecules & Therapeutics
2016 Volume.24 No. 1 p.67 ~ p.74
|
|
|
Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents
|
|
Lee Ju-Hee
Kim Hyun-Pyo
Sun Ya Nan
Lee Sang-Kook
Sun Ya-Nan
Kim Young-Ho
|
|
|
Abstract
|
|
|
|
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-β-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1β-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
|
|
|
KEYWORD
|
|
|
Acantopanax divaricatus var. albeofructus, Lung inflammation, Acanthoside, Macrophage
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|